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A The fixed-dose combination of irbesartan/hydrochlorothiazide (HCTZ) is approved in the US for use as initial therapy in patients who are likely to need multiple.1.1. Active ingredient olmesartan medoxomil/hydrochlorothiazide 1.2. Indication "Treatment of essential hypertension. COOLMETEC 40 mg/12.5 mg and 40 mg/25 mg fixed.

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